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<!-- Creation Date      : 2021-08-14T14:11:23.8924016+00:00 -->
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<!-- Package ID         : 9ce9bc11c38d436e8005d94e4df304b9 -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="tsha_ServicesAgreementMember" name="ServicesAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_OwnershipPercentageInExcessOfCapitalStock" name="OwnershipPercentageInExcessOfCapitalStock" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tsha_AdditionalConsiderationToRelatedPartyUnderOperatingAgreement" name="AdditionalConsiderationToRelatedPartyUnderOperatingAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tsha_DurhamLeaseMember" name="DurhamLeaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_DallasLeaseMember" name="DallasLeaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_PegasusParkLLCMember" name="PegasusParkLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_OperatingLeasesInitialDirectCosts" name="OperatingLeasesInitialDirectCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tsha_BuildToSuitAsset" name="BuildToSuitAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tsha_EquipmentPurchasesAndBuildOutOfLeasedFacility" name="EquipmentPurchasesAndBuildOutOfLeasedFacility" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tsha_ObligationForPaymentOfInitialBaseRentForOfficeSpace" name="ObligationForPaymentOfInitialBaseRentForOfficeSpace" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tsha_MaximumEstimatedMonthlyBaseRentIncreaseAnnuallyDuringTermOfLease" name="MaximumEstimatedMonthlyBaseRentIncreaseAnnuallyDuringTermOfLease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tsha_MaximumConstructionAllowanceProvidedByLandlordPerRentableSquareFoot" name="MaximumConstructionAllowanceProvidedByLandlordPerRentableSquareFoot" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tsha_NumberOfDistinctAndActiveClinicalStage" name="NumberOfDistinctAndActiveClinicalStage" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tsha_TermLoanThroughDecemberThirtyOneTwentyTwentyOneMember" name="TermLoanThroughDecemberThirtyOneTwentyTwentyOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_TermLoanFromJanuaryOneTwentyTwentyTwoUntilSeptemberThirtyTwentyTwentyTwoMember" name="TermLoanFromJanuaryOneTwentyTwentyTwoUntilSeptemberThirtyTwentyTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_TermLoanFromOctoberOneTwentyTwentyTwoUntilMarchThirtyOneTwentyTwentyThreeMember" name="TermLoanFromOctoberOneTwentyTwentyTwoUntilMarchThirtyOneTwentyTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_TermLoanFromAprilOneTwentyTwentyThreeUntilDecemberThirtyOneTwentyTwentyThreeMember" name="TermLoanFromAprilOneTwentyTwentyThreeUntilDecemberThirtyOneTwentyTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_TermLoanFacilityMember" name="TermLoanFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_TermLoanThroughAugustThirteenTwentyTwentyTwoMember" name="TermLoanThroughAugustThirteenTwentyTwentyTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_TermLoanThroughAugustThirteenTwentyTwentyThreeMember" name="TermLoanThroughAugustThirteenTwentyTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tsha_PercentageOfPrepaymentPremium" name="PercentageOfPrepaymentPremium" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tsha_PercentageOfPrepaymentOfFacility" name="PercentageOfPrepaymentOfFacility" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
</xsd:schema>
